Appetite + energy metabolism — a double hit
Built from two protocols
Step 1 · Reconstitution
Retatrutide · 10 mg vial
2 ml BAC water
Solvent
5 mg/ml
Concentration
MOTS-c · 40 mg vial
2 ml BAC water
Solvent
20 mg/ml
Concentration
| Dose | Syringe draw |
|---|---|
| 5 mg | 25 U |
Retatrutide syringe draw — see the dosing schedule above.
Step 2 · Dosing schedule
Step 3 · Administration
Retatrutide — subcutaneously into the abdomen, once a week on the same day (Sunday). MOTS-c — subcutaneously in the morning on an empty stomach, 30–60 min before food, 3 times/week (Mon-Wed-Fri). On training days — 1–2 hours before the workout.
Retatrutide works "from above" — reducing appetite via GLP-1, improving insulin via GIP, burning fat via GCGR. MOTS-c works "from below" — accelerating glucose and fatty-acid utilization at the mitochondrial level. Together: appetite suppression + increased energy expenditure = maximum effect.
Retatrutide — Sunday, one injection per week. MOTS-c — Monday, Wednesday, Friday. Both peptides run concurrently for all 12 weeks, but on different days. Do not combine both peptides on the same day unless necessary — spacing them across days reduces physiological load.
Advanced users with experience on at least one of the peptides. A weight-loss plateau on retatrutide monotherapy. Insulin resistance and metabolic syndrome. Low energy during a calorie deficit on GLP-1.
Monitor blood glucose — the combination can lower it significantly. Watch GI tolerability of retatrutide: nausea, satiety, appetite. Adequate hydration (2+ l of water) and protein 2 g/kg reduce the risk of side effects. If nausea is pronounced, hold the current titration step for 1–2 more weeks.
Strength training 2–3 times/week — preserving muscle mass. Protein 2 g/kg, creatine 5 g/day. MOTS-c works far more effectively with exercise — combine with training.
